Topsentins

Author: kxim

August undefined, 2024

WebA novel use for the class of biologically active bis-indole alkaloid compounds, which have been named topsentins, nortopsentins, or dragmacidins, pharmaceutical compositions containing them, methods of producing the compounds, and methods of using the compounds are disclosed. Specifically, the novel utility pertains to the anti-inflammatory … WebFrom a biogenetic point of view, the topsentins most probably derive from the condensation of two tryptamine units. In figure 1, the a - ketoimine 9, is assumed to be the key intermediate which dimerizes to form the imidazole ring(4). By analogy such an intermediate, or at least a

Topsentin - an overview ScienceDirect Topics

WebDownload scientific diagram Hypothetical biogenesis of topsentins and hamacanthins. from publication: Monoindole Alkaloids from a Marine Sponge Spongosorites sp. Seven … WebA new class of novel, biologically active bisindole alkaloid compounds, which have been named topsentins, pharmaceutical compositions containing them, methods of producing … overpopulation and poverty

Topsentia - Pherobase

Web21 18 Topsentins, new toxic bis-indole alkaloids from the marine sponge Topsentia genitrixl KRISTIN BARTIK, JEAN-CLAUDE BRAEKMAN , D~SIR~ DALOZE, AND CATHERINE STOLLER Unite' de chimie bio-organique, Faculte' des sciences, Universite' Libre de Bruelles, 50 Av. F. D. Roosevelt, I050 BrusseL-, Belgium JOELLE HUYSECOM AND GYSBLE VANDEVYVER … WebJun 1, 2008 · Topsentins and related bis-indole alkaloids may be efficiently synthesized through an addition/oxidation sequence leading to 2-(3-indolylcarbonyl)-imidazole derivatives followed by a Pd-catalyzed ... Web4.3.3.5.1 Key enzymes. The biosynthetic pathway of chitin can be thought of as consisting of two segments. The first set of reactions leads to the formation of the amino sugar, … overpopulation bill gates

Sponge secondary metabolites: new results - International …

Topsentins, new toxic bis-indole alkaloids from the …

WebA new class of novel, biologically active bisindole alkaloid compounds, which have been named topsentins, pharmaceutical compositions containing them, methods of producing the compounds and methods of using them are disclosed. This new class of compounds has the generic formula: ##STR1## R 1-8 are the same or different selected from --H, - … WebJun 16, 2008 · Topsentins and related bis-indole alkaloids may be efficiently synthesized through an addition/oxidation sequence leading to 2-(3-indolylcarbonyl)-imidazole derivatives followed by a Pd-catalyzed heteroarylation with the appropriate 3-stannylindoles. Graphical abstract. overpopulation and environmental impactsWebMay 31, 2013 · Topsentins are a group of structurally related bisindole alkaloids in which two indole fragments are connected by a carbonylimidazole linker (Table 1).The first … overpopulation:a problem or a myth

"WebDec 23, 2024 · Experiencing wide structural variations at both the imidazole moiety and the indole functionality, the succeeding analogs of topsentins include dragmacidins, hamacanthins, hytinadine A, nortopsentins, and rhopaladins from the genus Spongosorites and even a Rhopalaea sp. ascidian [23,24,25,26,27]. " - Topsentins

Topsentins

Synthesis and anticancer activity study of indolyl hydrazide

WebJul 25, 1991 · Abstract. Topsentin, a bis (indolyl)imidazole marine natural product, inhibited the proliferation of cultured human and murine tumor cells at micromolar concentrations … WebMar 15, 2000 · Chemical investigation of the Et2O extract of the marine sponge Rhaphisia lacazei resulted in the isolation of 13 pure bisindole alkaloids (1−13). Compounds (1−6) …

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WebApr 8, 2014 · Two new indole alkaloids, metagenetriindole A (1) and metagenebiindole A (2), were identified from deep-sea sediment metagenomic clone derived Escherichia coli fermentation broth. The structures of new compounds were elucidated by spectroscopic methods. The two new indole alkaloids demonstrated moderately cytotoxic activity … WebCompounds (1-6) belong to the class of topsentins and have already been described. Compounds 7-13 are new products, closely related to the class of hamacanthins. The …

WebFeb 1, 2024 · Topsentin is an anti inflammatory that may be helpful in treating diseases like arthritis. Topsentin also may be useful in protecting against colon cancer and Alzheimer’s … WebA novel use for the class of biologically active bis-indole alkaloid compounds, which have been named topsentins, nortopsentins, or dragmacidins, pharmaceutical compositions …

WebThree new bis-indole alkaloids, topsentin-A (1), -B1 (2), and -B2 (3) have been isolated from the Mediterranean sponge Topsentiagenitrix and their structure determined by …

WebJul 10, 2015 · Examples of bisindole alkaloids reported from marine sponges include the topsentins [15], which have a ketone and an imidazole moiety as a linker between two indole rings; the nortopsentins [26], ... overpopulation case study igcseWebOther compounds of interest are the ecteinascidins, potent antitumor agents currently in Phase III clinical trials for the treatment of cancer. A third series of compounds is the topsentins, potent anti-inflammatory agents discovered by HBOI scientists in collaboration with Professor Bob Jacobs of the University of California at Santa Barbara. overpopulation cause and effect overpopulation articleWebTopsentins are a group of structurally related bisindole alkaloids in which two indole fragments are connected by a carbonylimidazole linker (Table 1). The first representatives of this alkaloid type – topsentin A, or deoxytopsentin (3a), and also topsentin B1, or simply topsentin (3b), and topsentin B2, or bromotopsentin overpopulation cause povertyWebtopsentins, diazonamides and jasplakinolidcs; Figure 2) appear to be particularly important targets for biosynthetic studies because of their potent anti-inflammatory and anti-cancer activities. The marine haloperoxidases are thought to be involved in the biosynthesis of these natural products. overpopulation as a problem or a myth whyWebKeywords: chemistry, isolation, sponge, marine environment, anti-inflammatory activities, topsentins, synthesis Abstract: The marine sponges are the source of a unique group of natural products featuring a novel skeleton, the two indole rings were directed linked by a central heterocyclic moiety. overpopulation can lead to limitedWeb(1), labradorins (2), nortopsentins (3), topsentins (4) and meridianin (5), isolated from Arabidopsis thaliana, Pseu-domonas syringae pv. Coronafaciens, Spongosorites ruet-zleri, Topsentia genitrix and Aplidium meridianum, respectively, are found to be effective against various cancer cell lines (Diana et al., 2010; Kumar et al., 2014; overpopulation and water scarcity