Signal regulatory protein alpha
WebTyrosine-protein phosphatase non-receptor type substrate 1 (UniProt: P97797; also known as SHP substrate 1, SHPS-1, Brain Ig-like molecule with tyrosine-based activation motifs, … WebCD47 is a “don’t eat me” signal to phagocytes that is overexpressed on many tumor cells as a potential mechanism for immune surveillance evasion. CD47 and its interaction with signal-regulating protein alpha (SIRPα) on phagocytes is therefore a promising cancer target. Therapeutic antibodies and fusion proteins that block CD47 or SIRPα have been …
Signal regulatory protein alpha
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WebThe signal regulatory protein-β1 (SIRPβ1) is a DAP12-associated transmembrane receptor expressed in a subset of hematopoietic cells. Recently, it was shown that peritoneal … WebSignal Regulatory Proteins (SIRPs) comprise a family of several transmembrane glycoproteins (SIRPα, SIRPβ, and SIRPγ) that belong to immunoglobulin superfamily. …
WebMay 23, 2024 · Signal regulatory protein α (SIRPα), also known as cluster of differentiation (CD)172a or Src homology 2 domain‑containing phosphatase substrate‑1, is a cell surface … WebTyrosine-protein phosphatase non-receptor type substrate 1 (SHPS1) is also known as CD172 antigen-like family member A (CD172a), Macrophage fusion receptor, MyD-1 antigen, Signal-regulatory protein alpha (SIRPA or SIRP alpha) or p84, is a member of the SIRP family, and also belongs to the immunoglobulin superfamily.
WebIntegrin-associated protein (CD47) is a receptor for the cell-binding domain of thrombospondin (TSP) family members, a ligand for the transmembrane signaling protein … WebSPINDLY (SPY) is an important regulator of plant development, and consists of an N-half tetratricopeptide repeat (TPR) domain containing 10 TPR motifs and a C-half catalytic domain, similar to O-GlcNAc transferase (OGT) of animals. The best characterised role of SPY is a negative regulator of GA signalling, and all known spy alleles have been isolated …
WebCytoplasmic localization of calcium/calmodulin-dependent protein kinase I-α depends on a nuclear export signal in its regulatory domain (PDF) Cytoplasmic localization of calcium/calmodulin-dependent protein kinase I-α depends on a nuclear export signal in its regulatory domain Marina Picciotto - Academia.edu
WebOct 4, 2024 · Laminin is a large molecular glycoprotein heterotrimer assembled from different α, β, and γ chains. In 1979, Non-collagen glycoprotein were isolated from basement membrane-rich tumors and cells that produce basement membranes and purified into laminin. The LAMA2 gene encodes the subunit of Laminin α2 and is located on … in browser 3d designWebThe target genes of downregulated miRNAs were significantly related to gap junction, salivary secretion, and estrogen signaling pathway. has-miR-19a and hsa-miR-34a were significant nodes in the miRNA regulatory network. has-miR-19a was closely related to the AMPK signaling pathway. hsa-miR-34a was closely related to cellular senescence and … in browser anime gamesWebSpeed is critical in responding to a novel pathogen. Our cross-functional task force is developing products, processes and infrastructure to bolster our long-term preparedness … in browser antivirusWebThe anti-CD47 antibody or an antigen-binding fragment thereof is capable of blocking the interaction of CD47 with signal regulatory protein alpha (SIRPalpha). Further envisaged is an anti-CD47 antibody or antigen-binding fragment combined to … inc wedges sandalsWebMar 21, 2024 · SIRPA (Signal Regulatory Protein Alpha) is a Protein Coding gene. Diseases associated with SIRPA include Glioblastoma and Tenosynovial Giant Cell Tumor . Among … in browser animationWebCD172a, also known as SIRPα, is a type I transmembrane protein with one V-set Ig-like and two C-set Ig-like domains in the extracellular portion, and two ITIM motifs and a proline-rich region in the cytoplasmic tail. CD172a is expressed by monocytes, macrophages, myeloid cells, and neuronal tissue. inc western bootsWebProtein kinase B (PKB/Akt) has come indicated to play a role in protection after apoptosis, cell reproduction press cell growth. It is also involved in matchmaking the influences for insulin, such as lipogenesis, glucose usage and modification of glucose into fatty acidic and fat. Sterol-regulatory element obligation organic (SREBPs) are the major transcription … inc what i know podcast