Phospho-eif2α ser51 d9g8

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August undefined, 2024

WebJan 1, 2024 · Primary monoclonal antibodies (clone name; catalog number) used were phospho-eIF2α Ser51 (D9G8; 3398), eIF2α (D7D3; 5324), phospho-p70 S6 kinase Thr389 (1A5; 9206), p70 S6 kinase (49D7; 2708), and α-tubulin (11H10; 2125) were obtained from Cell Signaling Technologies (Danvers, MA). WebJan 6, 2024 · Activation of PERK leads to phosphorylation of the eukaryotic initiation factor 2α (eIF2α), which is a critical regulator of protein translation. Phosphorylated eIF2α prompts a dramatic reduction in protein translation to limit cellular amino acid consumption.

Phospho-EIF2S1 (Ser51) Recombinant Monoclonal …

WebMay 3, 2024 · Stress-responsive kinases phosphorylate eIF2α at conserved Ser51, transforming eIF2 from substrate into a competitive GEF inhibitor. ... yet eIF2Bα deletion impairs phospho-inhibition of eIF2B, consistent with the subunit’s role in binding eIF2α-P. Point mutations with identical phenotypes cluster at the interface between eIF2Bα and ... WebPhospho-eIF2α (Ser51) (D9G8) XP ® Rabbit mAb 仅在 Ser51 位点被磷酸化时检测 eIF2α 内源性水平。这种抗体不能检测在其他位点被磷酸化的 elF2α。物种反应性：人, 小鼠, 大鼠, 猴, 黑腹果蝇来源/纯化使用与人 … how to size a home generator for your house

CRISPR-Cas9-mediated knockout of GCN2 reveals a critical role in ...

WebMonoclonal Antibody for studying EIF2S1/eIF2-alpha (Ser52) phosphate. Cited in 5 publications. Validated for Western Blotting. Highly specific and rigorously validated in … Web5199 Phospho-eIF2α (Ser51) (D9G8) XPÒ Rabbit mAb (Biotinylated) 2.2. Kennzeichnungselemente Ergänzende Gefahrenmerkmale EUH210 - Sicherheitsdatenblatt auf Anfrage erhältlich 2.3. Sonstige Gefahren Kann allergische Reaktionen hervorrufen. Den vollen Wortlaut der H-Sätze und EUH-Sätze in diesem Abschnitt finden Sie in Abschnitt 16 Web产品名称： eIF 2 α（总）和eIF 2 α（磷酸化Ser 51）TR-FRET检测试剂盒 - 【干冰】eIF2α (Total) and eIF2α (Phospho-Ser51) TR-FRET Assay Kit. 产品货号：500205-480. 产品规格：480wells. 背景资料：该eIF 2 α（总）和eIF 2 α（磷酸化Ser 51）TR-FRET检测试剂盒,【干冰】eIF2α (Total) and eIF2α ... nova mahindra world city

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Phospho-eIF2α (Ser51) (D9G8) XP® Rabbit mAb Cell Signaling …

WebAntibody Duet for studying EIF2S1/eIF2-alpha/EIF2S1/eIF2-alpha (Ser52) phosphate in the research area. Web(3398) Phospho-eIF2α (Ser51) (D9G8) XP® Rabbit mAb Supplier Cell Signaling Technology. Host Rabbit Type Primary Clonality Recombinant (D9G8C8D5) Recombinant Yes Conjugate Unconjugated Target Eukaryotic translation initiation factor 2 subunit 1 (Human) UniProt P05198 - IF2A_HUMAN. Gene nova magnetic storm worksheet answer keyWebtarget protein. Phospho-eIF2α (Ser51) (D9G8) XP® Rabbit mAb detects endogenous eIF2α only when phosphorylated at Ser51. The antibody does not recognize elF2α phosphorylated at other sites. Phospho-SAPK/JNK (Thr183/Tyr185) (81E11) Rabbit mAb detects endogenous levels of p46 and p54 SAPK/JNK only when phosphorylated at Thr183 and … nova mack heavy duty rolling walker

"Phospho-eIF2α (Ser51) (D9G8) XP ® Rabbit mAb detects endogenous eIF2α only when phosphorylated at Ser51. The antibody does not recognize elF2α phosphorylated at other sites. Human eIF2alpha residue Ser52 historically has been referenced as Ser51. Species Reactivity: Human, Mouse, Rat, Monkey, D. melanogaster " - Phospho-eif2α ser51 d9g8

Phospho-eif2α ser51 d9g8

Webgsk2606414是一种选择性的perk抑制剂，ic50值为0.4 nm[1]。 prkr样内质网激酶或蛋白激酶r（pkr）样内质网激酶（perk），也被称为真核翻译起始因子2-α激酶3（eif2ak3），属于i型膜蛋白家族。perk位于内质网（er）中，被错误折叠蛋白引起的er应激所诱导。perk通过磷酸化真核翻译起始因子2（eif2）的α亚基，从而 ... WebSpecificity / Sensitivity Phospho-eIF2α (Ser51) (D9G8) XP ® Rabbit mAb detects endogenous eIF2α only when phosphorylated at Ser51. The antibody does not recognize elF2α phosphorylated at other sites. Human eIF2alpha residue Ser52 historically has been referenced as Ser51.

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WebApr 8, 2024 · The data indicate that the phospho-JNK, phospho-eiF2α, ATF4, and CHOP levels are upregulated as early as 3 h after treatment with NB extract. A slight induction in cell death, as shown by the increase in cleaved PARP, was shown at 6 h after treatment with NB extract, which became more significant after 24 h. WebThe inhibition of Hsp90 prolonged ERS through the degradation of IRE1α and the dephosphorylation of eIF2α. • The suppression of autophagy reduced the expression of GRP78 and phospho-eIF2α to aggravate ERS. • Hsp90-mediated UPR and mTOR-dependent autophagy jointly promoted ERS-induced apoptosis in As 3+ /Se 4+ combination-treated …

WebSep 28, 2024 · Primary antibodies against LC3A/B (4108S), PERK (C33E10) (3192S), phospho-PERK (Thr980; 16F8) (3179S), eIF2α (D7D3) XP ® (5324T), and phospho-eIF2α … WebPhospho-eIF2α (Ser51) (D9G8) XP ® Rabbit mAb (Biotinylated) detects endogenous eIF2α protein only when phosphorylated at Ser51. This antibody does not recognize elF2α …

WebPhospho-eIF2α (Ser51) (D9G8) XP® Rabbit mAb an Antibody by Cell Signaling Technology. Applications: WB. eIF2α Antibody an Antibody by Cell Signaling Technology. Applications: WB. Anti-α-Tubulin pAb-HRP-DirecT (Polyclonal Antibody) an Antibody by MBL International. ... WebStructural information on eIF2α reveals that Ser51 is located within a flexible loop, referred to as the Ser51 loop. Recently, we have shown that conformational change of the Ser51 loop increases the accessibility of Ser51 to the kinase active site for phosphorylation.

WebSep 16, 2016 · The integrated stress response (ISR) is a cytoprotective pathway initiated upon phosphorylation of the eukaryotic translation initiation factor 2 (eIF2α) residue designated serine-51, which is...

WebOur data also show that the protein levels of ATF4, a down-stream factor up-regulated by eIF2α phosphorylation, significantly increase at 3 h after 50 mJ cm −2 only after using the UVB lamp (Fig. 3C, Lines 2 versus 1) and at 3 h after 200 mJ cm −2 when using the UVB/UVA lamp with and without the filter (Fig. 3C, Lines 6, 7 versus 1). how to size a hot water tankWebInvitrogen Anti-Phospho-EIF2S1 (Ser51) Recombinant Monoclonal (10H21L20), Catalog # 701268. Tested in Western Blot (WB), Immunocytochemistry (ICC/IF) and … how to size a hot water boilerWebNov 19, 2024 · The phosphorylation of eIF2α is controlled by four protein kinases, general-control non-derepressible-2 kinase (GCN2), double-stranded RNA-activated protein kinase (PKR), haeme-regulated inhibitor kinase (HRI), and PKR-like endoplasmic reticulum kinase (PERK) ( Ohno, 2014 ). how to size a hydraulic pumpWebJun 8, 2024 · The phosphorylation of eIF2α occurs on serine 51 in response to the activation of one out of four eIF2α kinases 4, 5, 6. EIF2AK1, commonly known as heme-regulated … how to size a i beamWebSep 3, 2024 · Product-Name : Phospho-eIF2α (Ser51) (D9G8) XP® Rabbit mAb Size : 40 ul Price- (USD) : 135 USD Species-x-Reactivity : H, M, R, Mk, Dm Applications : Immunohistochemistry (Paraffin) Product-Category : Translational Control Shipping-Temp : AMBIENT Storage-Temp : -20°C Product-Type : Monoclonal Antibody MW : 38 Host : … how to size a hydraulic systemWebAnti-phospho-eIF2 α (pSer51) antibody produced in rabbit affinity isolated antibody Synonym (s): Anti-EIF-2, Anti-EIF-2A, Anti-EIF-2alpha, Anti-EIF2, Anti-EIF2A NACRES: NA.41 Pricing … nova making stuff colderWeb(3398) Phospho-eIF2α (Ser51) (D9G8) XP® Rabbit mAb - Cell Signaling Technology - CiteAb 726 citations – A rabbit monoclonal antibody, raised against Eukaryotic translation … nova madison wi