WebInstitute of Biophysics, CAS Address: 15 Datun Road, Chaoyang District, Beijing, 100101, China Tel:8610-64889872 Fax: 8610-64871293 E-mail: [email protected] Web8 sept. 2024 · Here we report the crystal structure of the IpaH7.8-GSDMB complex, which shows how IpaH7.8 recognizes the GSDMB pore-forming domain. We clarify that IpaH7.8 targets human (but not mouse) GSDMD through a similar mechanism. The structure of full-length GSDMB suggests stronger autoinhibition than in other gasdermins 9,10 .
Chunlai Chen_清华大学结构生物学高精尖创新中心
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